SDF Chatter

Police said Preston Ordone had been ‘improperly restrained’ when his parents’ pick-up truck veered off the interstate, but his grandfather disputed that

An American sailor sustained minor injuries Monday when Navy fighter jet toppled off an aircraft carrier and sank into the Red Sea, reportedly during a Houthi strike.

Otto Warburg originally proposed that cancer arose from a two-step process. The first step involved a chronic insufficiency of mitochondrial oxidative phosphorylation (OxPhos), while the second step involved a protracted compensatory energy synthesis through lactic acid fermentation. His extensive findings showed that oxygen consumption was lower while lactate production was higher in cancerous tissues than in non-cancerous tissues. Warburg considered both oxygen consumption and extracellular lactate as accurate markers for ATP production through OxPhos and glycolysis, respectively. Warburg’s hypothesis was challenged from findings showing that oxygen consumption remained high in some cancer cells despite the elevated production of lactate suggesting that OxPhos was largely unimpaired. New information indicates that neither oxygen consumption nor lactate production are accurate surrogates for quantification of ATP production in cancer cells. Warburg also did not know that a significant amount of ATP could come from glutamine-driven mitochondrial substrate level phosphorylation in the glutaminolysis pathway with succinate produced as end product, thus confounding the linkage of oxygen consumption to the origin of ATP production within mitochondria. Moreover, new information shows that cytoplasmic lipid droplets and elevated aerobic lactic acid fermentation are both biomarkers for OxPhos insufficiency. Warburg’s original hypothesis can now be linked to a more complete understanding of how OxPhos insufficiency underlies dysregulated cancer cell growth. These findings can also address several questionable assumptions regarding the origin of cancer thus allowing the field to advance with more effective therapeutic strategies for a less toxic metabolic management and prevention of cancer.

Full Paper https://doi.org/10.1007/s10863-025-10059-w

Alaraby Network has been added to LMAN as channel 264

Alaraby Network has been added to LLIV as channel 264

cross-posted from: https://lemm.ee/post/62648503

cross-posted from: https://metawire.eu/post/55971

The unfavorable poll comes as Musk prepares to step back from the Trump administration to devote more time to his businesses

Something I made on the fly

Robin of the Wood (128k intro) by Fred Gray

./r/RobinOfTheWood.ay?#0
Title: Robin of the Wood (128k intro)
Author: Fred Gray
#ZXSpectrum
#chiptune

I wonder what happened to warrant that.

They’d watched overnight as the bombardments grew closer, and observed through binoculars as the final U.S. Marines piled into a helicopter from the roof of the embassy to be whisked away

What do you do on wash day and between?

mine: wash day, Malibu C hard water shampoo, Innersense Hydrating conditioner, their Serenity Styling cream. Comb it through, flip head over and rake it through upside down. Scrunch, then scrunch with a soft microfiber towel. Wrap it in the same damp towel (between a plop and turbo twist arrangement) while doing skincare. Then let the hair down and gently clap some gel through, diffuse (sometimes hovering, sometimes scrunching, depends on how it's looking).

Refresh, everything except the shampoo.

Mini-refresh, sometimes I can smooth on some mousse or foam and the added definition is enough. Sometimes it looks good and I can hairspray. If it's stretched out those don't work though.

April 28, 2025

Context is Zip Comics #7, page 24

Transcript:

Narration: Suddenly…!

Nevada Jones: Don't resist, Little Joe—it's better to let them take us

Majority vs minority still TBD at the moment.

Try it!

I haven’t seen another Lemmy client that lets you write code in your post with real-time syntax highlighting. It’s not just code. Write your posts in rich text without toggling between Markdown and preview.

There are a lot of Lemmy clients, so I’m sure someone else does this. But I wanted to share in case anyone else finds this helpful.