When it comes to astrophysics, you may as well quote deadpool: "Maximium effort"

Nothing has in the last century (a time when we have had thousands of astrophysicists working on it) to dismiss the limits that are inherent in space-time as Einstein described.

Humans may get the trip to Alpha Centauri down to 80 years of so, (accelerating to 10% of c at the halfway point) but that is literally next door.