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GOOD games with female protagonists?
(beehaw.org)
From video gaming to card games and stuff in between, if it's gaming you can probably discuss it here!
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The Longest Journey, Dreamfall, Dreamfall Chapters
This is what I was coming here to recommend. April is a great character, and the series is really good. The first is very much old-school point & click, with the sometimes highly obscure puzzles that entails, but the story is excellent.