Science

https://archive.ph/9L36A

Now, millions more people will soon have access to this painkiller — a drug called suzetrigine that works by selectively blocking sodium channels on pain-sensing nerve cells and delivers opioid-level pain suppression without the risks of addiction, sedation or overdose. On Thursday, the US Food and Drug Administration approved suzetrigine for short-term pain management, making it the first pain drug given a regulatory nod in more than 20 years that works through a brand-new mechanism.

"This is a big step forward," says Stephen Waxman, a neuroscientist at the Yale School of Medicine in New Haven, Connecticut.

"Anything we can add to the toolbox that will allow us to reduce opioid dependency is a significant positive," says Paul White, an anaesthesiologist at the Cedars-Sinai Medical Center in Los Angeles, California, who was involved in suzetrigine's development.

Article is in Nature but paywalled so I shared archive.

BBC video: Archaeologists make ‘once-in-a-century’ discovery at Pompeii

A bio-archaeologist with the University of Reading, in the U.K., has found an ancient dog's red-painted penis bone along with a trove of other bones, in an ancient Roman era quarry shaft. In her paper published in the Oxford Journal of Archaeology, Ellen Green describes where the bone was found, its condition, and possible reasons for it being painted red.

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Green states that during Roman times, the penis, or depictions of it, were used in many contexts, many of which involved hoping for good luck. She suspects that the bone from the shaft likely played a role in a ritual of some sort, either before being tossed into the quarry shaft, or during its internment. She notes that other objects found in the shaft support the idea that the bone could have played a role in a larger ritual—perhaps one related to fertility.

[...]

Back in 2019, we told you about an intriguing experiment to test a famous anthropological legend about an elderly Inuit man in the 1950s who fashioned a knife out of his own frozen feces. He used it to kill and skin a dog, using its rib cage as a makeshift sled to venture off into the Arctic. Metin Eren, an archaeologist at Kent State University, fashioned rudimentary blades out of his own frozen feces to test whether they could cut through pig hide, muscle, and tendon.

Sadly for the legend, the blades failed every test, but the study was colorful enough to snag Eren an Ig Nobel Prize the following year. And it's just one of the many fascinating projects routinely undertaken in his Experimental Archaeology Laboratory, where he and his team try to reverse-engineer all manner of ancient technologies, whether they involve stone tools, ceramics, metal, butchery, textiles, and so forth.

This video is a bit older now (over one year), but I just found about it. And I want to share it here, because it was very well explained, without boring stock videos or background music. It's just like a teacher would teach you, but with some enthusiasm behind it. I enjoy his videos so far.

• Watch on YouTube: https://youtu.be/Zkv8sW6y3sY
• Watch on Invidious, a more private and indirect way to watch: https://inv.nadeko.net/watch?v=Zkv8sW6y3sY

Video description:

Why is the speed of light the same in all reference frames? Let's rediscover the thought experiments that led Einstein to his special theory of relativity

Chapters:

00:00 Introduction
01:15 1/3 Detect motion with particles? (Thought experiment)
04:01 Inertia doesn't allow detecting constant velocity motion
06:18  2/3 Detect motion with waves? (Thought experiment) 
09:18 Medium doesn't allow detecting constant velocity motion
10:15 Constant velocity motion is RELATIVE!
11:02 3/3 Detect motion with light? (Thought experiment)
13:12 Does light break relativity? 
13:46 Michelson & Morley's experiment (oversimplified) 
14:20 The logical conclusion - Speed of light is same in all frames

Brain structure can tell us a lot about reading skills. Importantly, though, the brain is malleable — it changes when we learn a new skill or practice an already acquired one.

For instance, young adults who studied language intensively increased their cortical thickness in language areas. Similarly, reading is likely to shape the structure of the left Heschl’s gyrus and temporal pole. So, if you want to keep your Heschl’s thick and thriving, pick up a good book and start reading.

[...] it’s worth considering what might happen to us as a species if skills like reading become less prioritised. Our capacity to interpret the world around us and understand the minds of others would surely diminish. In other words, that cosy moment with a book in your armchair isn’t just personal – it’s a service to humanity.

An excellent video about how (long) covid and other diseases/pandemics are awful and how capitalism and governments loves to ignore them in hopes that things will 'carry on' as normal thus creating social stigma and work policies that disable people more and more.

When digging a pit, one way to prevent the walls from collapsing inward under pressure is to make them less steep, so they slant outward like the sides of a cone. A good rule of thumb is to make the hole three times wider than its depth.

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Suppose you were to try digging through the Earth, and that the planet was all solid. (We know that it’s not, but this is the simplest scenario.) The depth of a hole all the way through the planet would be equivalent to Earth’s diameter, which is just a name for a line that passes straight through the center of a circle. So your hole would need to be about three times as wide as the diameter of the Earth in order for it to be stable.

Clearly, this is an impossible task that would completely alter the planet’s shape.

[...]