I'm on hybrid Intel/Nvidia, and it works fine. The discrete card isn't particularly powerful, so I don't use it much, but it works pretty much as I would expect. If you're wary, just try on a live USB. It won't harm your computer as long as you check it's working before installing, and if it works on there it should work once installed. Might be best to start with a distro that at least has a toggle for proprietary drivers in the installer though, so you don't have to do any faffing about yourself.