Honestly the whole blunted effects are really not all that blunted, visuals are still definitely there (especially if you consume cannabis at any point, though I'd also caution against for your first time, and suggest being cautious if you choose to smoke it during the experience even if you do smoke it regularly)

It would be useful to know which SSRI you're talking about to gauge possible contraindications...

LSD and mushroom are both safe with Sertraline (Zoloft)

Mescaline should also typically be fine.

DMT will have heavily blunted effects, so likely not with the effort.

Major contraindications for psychedelics are MAOIs, Lithium, and possibly tricyclic antidepressants (though the I could be misremembering the last one).

DXM is a 50/50, slight risk of Serotonin syndrome at higher doses if also on medications which are metabolized by the same enzyme pathways

My wife is on SSRI's. It takes her twice as long as me to feel the effects of LSD and Psilocybin and they seem to last a shorter duration, but the effects are not blunted. Could be down to biology/metabolism.

I would also like to know.