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Why we don't have 128-bit CPUs
(www.xda-developers.com)
This is a most excellent place for technology news and articles.
We can, but it's awkward to do so. By having everything work with powers of 2 you don't need to have everything the same size, but can still pack things in memory efficiently.
If your registers were 48bits long, you can use it to store 6 bytes, or 3 short ints, but only one int with 16-bits going unused. If they are powers of two in size, you can always fit smaller things in them with no wasted space.
A better example is to explain the chaos of having to go to the grocery store and pick up some hot dogs and buns. You know the pain.