So general flow chart here starts with context. When an actor plays a character that character's gender is considered before the actor.

In this case this picture is from Umbrella Academy but before the character comes out as a trans man. The role was specifically altered for Page by the show runners to make the role more comfortable for the actor (he offered to delay transition goals for the production but the production being incredibly awesome decided that this was something they could flex) so this meme is referencing one of the most recognizable trans actors in the world in a part where the character's coming out was basically happening during Page's transition.

Since the character is trans but this pic is before the transition it follows real world etiquette where pre transition photos should use current preferences of identity.

So the answer is from the trans community standpoint is that unless you jumped out of the series before that reveal and were fully unaware then yeah, making this meme with this pic with this specific context is pretty gauche but an easy mistake.