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It would be pretty hard. There’s a reason quantum mechanics is the current explanation, and it doesn’t start with the Bell entanglement experiments.
Black body radiation would have some bizarre behavior without quantum mechanics.
The radiation spectrums of stars are also very dependent on quantum mechanics.
Some related phenomena such as transistors and phosphorescence are hard to explain without quantum mechanics.
A big one is chemistry is highly dependent on quantum mechanics. You could have a limited understanding of ionic compounds with just the Columbic force, but covalent bonds require quantum mechanics to explain.
Most of physics history is studying the edge cases and gaps in the current understanding, and filling those in. Quantum mechanics didn’t just appear suddenly; it was derived as an explanation for many previously unexplained phenomena in pieces my many different people over time.
If you did come up with an alternative explanation, you would have to reinvent just about everything. Ever seen what it would take for the flat earth idea to hold water? Yeah, that level of reinvention plus some more of that vibe.
But let’s say that in this alternate universe those wild models are actually true, valid and they end up producing a universe that looks like ours. Since it’s based on completely different physics, there will also be some strange differences. Even if those galaxies look like ours, it doesn’t mean that biochemistry or life would be possible.