this post was submitted on 11 Jun 2025
20 points (69.2% liked)

You Should Know

63 readers
1 users here now

What do you know the rest of us might not?

Please share interesting facts that help provide a more complete picture of the world we're living in.

  1. Posts and comments must be true and supported by verified, factual evidence

  2. Posts must begin with the acronym "YSK"

  3. No misinformation/propaganda/alarmist claims

  4. Be civil to other users

Please report any violations

founded 1 month ago
MODERATORS
 

caffeine only needs 190 mg per kilogram of body weight to have a 50/50 chance of killing you, whereas you would need 280 mg per kilogram of body weight of psilocybin.

caffeine

psilocybin

you are viewing a single comment's thread
view the rest of the comments
[–] Sturgist@lemmy.ca 2 points 3 weeks ago (1 children)

Healingmaps dose guide.

The strain available locally where I grew up was psilocybin cubensis. Golden Teachers were the more common variety, Penis Envy was occasionally available.

Note that I am talking about consuming DRY mushrooms. 25g of fresh mushrooms is about 2.5g dry. For cubensis that's a moderate but not insane dose. 25g dry is closer to 250g wet.

Psychedelic Support.

Synthetic Psilocybin Doses in Research

For research studies, a synthetic or extracted version of psilocybin is typically used. The psilocybin molecule is produced in a laboratory, meaning no mushrooms are needed. Extraction methods isolate psilocybin from mushrooms. Pure psilocybin in capsules allows researchers to administer a precise and consistent dose to all clinical trial participants. Since they are not using dried mushrooms, the dosage is given as milligrams of synthetic psilocybin. Some studies even take into account a person’s body weight and give doses as mg of psilocybin/kg of body weight or as mg of psilocybin/70kg (the average human weight), but at least one study did not find differences in how people felt when doses were adjusted for body weight [2].

Here are example doses of psilocybin (note: not dried magic mushrooms) given in research studies. Most people will notice some small perceptual shifts after taking 2-4 mg of psilocybin. Psychoactive effects are experienced after ingesting 8-20 mg, with the majority of people reporting mystical experiences at a dose of 20 mg or higher [4].

-10 mg psilocybin – low dose.
-20-30 mg psilocybin – medium or standard dose.
-30-40 mg psilocybin – high dose.
->40 mg psilocybin – very high dose. Hi

Synthetic or Extracted Psilocybin vs Mushroom Dosage

You may be wondering how extracted or synthetic psilocybin doses compare to dried mushrooms.

As a comparison for dosage [3], there is typically 1% psilocybin per 1 gram of dried Psilocybe cubensis mushrooms. For example, 3.5 grams (equivalent to an eighth ounce) of dried Psilocybe cubensis is likely to contain 35 mg of psilocybin (high dose), and 2.0 grams of dried mushrooms contain 20 mg of psilocybin (standard dose). Keep in mind that psilocybin levels in dried mushrooms can vary quite a bit between species, ranging from 0.1% to 2% of dry weight. Mushroom caps usually have higher psilocybin levels than mushroom stems.

To use your own sources.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9751063/

Your fist link says they use a set 25_mg_ dose of extracted psilocybin.

https://erowid.org/experiences/exp.php?ID=91095

The person recounting this trip consumed 2.6g of dried mushrooms and had a very intense trip. That should be about 26mg of psilocybin.

My experience on 25g of dried mushrooms was likely around 250mg of psilocybin.

Does this count as bringing sources to the table?
Or are you going to delete my comments again?

[–] Varyk@sh.itjust.works 1 points 3 weeks ago* (last edited 3 weeks ago)

"does this count as bringing sources to the table?"

yes, providing relevant sources counts as "bringing sources to the table".

"are you going to delete my comments again?"

nope, your previous comments were deleted for alarmism and lacking sources.

now you are sharing your own experience and general facts about psilocybin dosage supported with evidence.

looks good to me.