Can I add Mods? Then Skyrim VR.

If I can't, I'd choose a Game as a Service type of deal, if we could also make the assumption that the game would also be actively developed for the rest of my life.
Destiny 2 comes to mind, because I really love the lore and the gameplay.

If we can't add mods or the game won't be updated for the rest of my life, I'd still choose Destiny 2. After it gets cancelled, I'd just go outside and touch grass then, I guess. 😅