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Phasers set to "Bitch please"
(startrek.website)
Star Trek memes and shitposts
Come on'n get your jamaharon on! There are no real rules—just don't break the weather control network.
TNG was close to having a transgender episode, "The Outcast", but they were stuck in their time and didn't really make any kind of statement.
TOS made several comments on religion and running into powerful beings. In particular "Who Mourns for Adonais?", which would've been a great take if not for Kirk saying "Mankind has no need for gods. We find the one quite adequate".
I thought having Riker fall in love with one of the enby people was about as close to a statement of support as they could get in the 90s.