I personally prefer kindle over traditional books just because I can read at night with the kindle and the kindle is lighter than books.

I think reading comprehension is the same, although my very weak arms get tired when reading the book while holding it up while I'm in bed and then I have to go to the next page, and sometimes accidentally go 2 pages forward so it does get distracting in that sense.

I know a lot of people really like physical books because of sentimental/ritualistic reasons though and setting up a kindle/nook is a hassle for them