Body chemistry works on a cadence, so there is that. Dopamine and serotonin (and most neurotransmitters, speaking generally) have their own ebb and flow over the course of the day and likely through the year as well.

Again, there is a mild point to be made here and I am trying to leverage your choice of words with my own personal perspective. (It's a bit redundant, TBH. I just feel the need to elaborate a little more for anyone else reading.)

To my understanding, most psychotropic medications (all classes of drugs designed to alter brain chemistry) are intended to work in concert with our natural cycles. If there is one thing that I know with certainty, is that SRIs, SNRIs, etc., absolutely must be taken on a consistent schedule for this reason, regardless of what a person's state of mind is at any particular moment.

It makes logical sense that psilocybin and other psychedelics that function similar to, or better than, existing antidepressants may need to be taken on a regular basis as well. This is the theory behind microdosing, anyway. (I personally believe it may be more complicated and/or nuanced than what microdosing proponents say, but that is neither here nor there.)