If it isn't working in MSI center then it sounds like maybe a corrupt firmware on the LED controller on your motherboard. Is there a firmware updater in MSI center? I know people have mentioned newer boards getting automatically updated. MSI's older RGB controller firmware had bricking issues and we were able to reflash these older motherboards using the JT1 header and a Nuvoton NuLink adapter, but those bricked boards the USB device never even showed up to the rest of the system. I haven't heard of this specific issue before where it shows up but is uncontrollable. Have you tried using pipeline version of OpenRGB?

Finally figured it out. Had my controller using a preset of its own; I had to change the mode to mobo controlled. Sorry about that!!

So I now have direct control with just some weirdness. The colors do not correspond to what is set; there appears to be some mapping or shift in play. And the brightness controller also just loops on itself. And finally for effects like “Breathe”, instead of the smooth dimming, it just has a stepped (discrete) effect, not continuous.