Fun fact, this comic is where the term "weeb" comes from: https://knowyourmeme.com/memes/weeaboo
~~I don't remember where I saw it, but~~ "weeaboo" is an intentionally nonsense word here, and it was picked because the author's sister described a dream she had to him where people were shouting it. I saw a store called "weeb" the other day, and thought it was kind of funny that the store's name derived from someone's weird dream 20 years ago.
EDIT: Here's the AMA where the author mentions the source: https://web.archive.org/web/20250413175535/https://old.reddit.com/r/IAmA/comments/2plhgn/iama_guy_who_does_the_perry_bible_fellowship_ama/cmxyxlz/
The correlation between the appropriation, the comic strip, and its true origin is sublimely meaningless. The word "Weeaboo" comes from a dream my sister had- in which a large room of Victorian-era people were shouting it at her, repeatedly.