Nix / NixOS

I'm afraid it's difficult to provide a simple example as there are a bunch of moving parts.

In essence, you create a file (e.g. module.nix) in your package repo:

self:
{
  config,
  pkgs,
  lib,
  ...
}:
let
  cfg = config.programs.my-package;
in
{
  # Here we define the options that we can tweak and configure.
  options = {
    programs.my-package = {
      # Whether to configure anything in the first place
      enable = lib.mkEnableOption "my package";
      # Which colors to use
      colors =
        let
          # This is just a function to reduce boilerplates. It generates options from the name of the color setting
          color =
            name:
            lib.mkOption {
              description = "${name} color for my-package";
              type = lib.types.str;
            };
        in
        {
          bg = color "Background";
          fg = color "Foreground";
          # other colors here too
        };
    };
    # Whether to use stylix to configure colors
    stylix.targets.my-package.enable = lib.mkEnableOption "Stylix configuration for my-package";
  };
  # Here we set up our package (if programs.my-package.enable is true)
  config = lib.mkIf cfg.enable {
    # Add our package to home.packages (you're doing this already, we're just moving it here for convenience)
    home.packages = [ self.packages.${pkgs.system}.my-package ];
    # Here is the part where we do the actual configuring. This depends on how your package reads its configuration.
    xdg.configFile."my-package/colors.toml".text = ''
      <somehow generate the config file using ${cfg.bg} and ${cfg.fg} etc
    '';
    # This is a bit recursive but should be fine. If if throws errors about infinite recursion then tell me :)
    # Here we set the default values for the colors in our configuration to whatever is provided via stylix (provided you enable the corresponding config setting)
    programs = lib.mkIf stylix.targets.my-package.enable {
      my-package.colors.bg = lib.mkDefault config.stylix.colors.base00;
      my-package.colors.fg = lib.mkDefault config.stylix.colors.base05;
      # etc
    };
  };
}

Then you make sure your program reads the colors from ~/.config/my-package/colors.toml (you can use whatever format or path you want, but adjust the module accordingly), and uses those colors

Finally, you add homeModules.default = import ./module.nix self; to your package flake, and imports = [ inputs.my-package.homeModules.default ]; programs.my-package.enable = true; stylix.targets.my-package.enable = true; to your home-manager configuration. You will need to adjust a lot of stuff depending on how exactly you want to do this but this should get you started.

All of this is a bit complicated but I think for a good reason; this setup is really quite flexible and will allow you to expand easily in the future should you continue work on the project. And if not, it gives you a chance to learn about a lot of different Nix concepts that will come in useful later :)