[-] jpritikin73@lemmy.today 2 points 2 weeks ago

I use ayahuasca in the context of the Santo Daime. Part of the Santo Daime aesthetic is to behave as if you are sober. That's what I mean by adapt.

[-] jpritikin73@lemmy.today 2 points 2 weeks ago

"The effects potentiate each other, so you will be tripping much harder." -- This is not how I experienced it. To me, the effects of each substance are pretty orthogonal. The combination is not multiplicative or even additive. It's more like being on two separate substances that affect different aspects of experience. However, the cannabis made me less able to adapt as the force of the ayahuasca got stronger.

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Since I enjoy cannabinol (CBN), I'm curious to learn about the acetylated version CBN-O. I've heard that CBN-O is stronger than CBN, but can anybody suggest anything more specific? Is CBN-O 10x stronger than CBN? What about duration? Is CBN-O more than 8 hour duration?

[-] jpritikin73@lemmy.today 2 points 2 weeks ago* (last edited 2 weeks ago)

Now that I've experimented with the combo, I would say that cannabis interferes with the profound impartiality of ayahuasca. I enjoy ayahuasca more without cannabis.

[-] jpritikin73@lemmy.today 1 points 2 months ago

I agree. I found Psychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey that mentions, "cannabis smoked together with ayahuasca during ceremonies of the Brazilian Santo Daime Church." So I guess the combo is metabolically fine.

[-] jpritikin73@lemmy.today 1 points 2 months ago

Thanks for your concern with my psychological state, but I'm just asking if there is metabolic a counter-indication like for mixing alcohol and opioids. Or the combo of warfarin and ibuprofen.

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submitted 2 months ago* (last edited 2 months ago) by jpritikin73@lemmy.today to c/psychedelics@lemmy.ca

Any drug interaction that I should be worried about?

[-] jpritikin73@lemmy.today 1 points 6 months ago* (last edited 6 months ago)

Yep, I expect to post contradicting evidence soon. The current theory is that psilomethoxin is soluble in water but not methanol.

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submitted 6 months ago* (last edited 6 months ago) by jpritikin73@lemmy.today to c/psychedelics@lemmy.ca

Church of the Sacred Synthesis March 7 Press Release

The Church of the Sacred Synthesis (The Church) is pleased to announce that it has confirmed the presence of Psilomethoxin (4-HO-5-MeO-DMT) in its mushroom fruiting bodies.

These findings have been independently confirmed using triple quadrupole LC/MS instrumentation at the Chemical Purification, Analysis, and Screening Facility supervised by its director at the University of South Florida (USF) on Tuesday March 5, 2024.

The Church made the Psilomethoxin reference standard that it promised and will be able to test submitted sacramental Psilomethoxin contained in fruiting bodies provided by others who grow the sacrament on their own.

The Church has a distribution partner who will be making Psilomethoxin available over the counter (OTC) in a GMP formulation. We have a biotech partner who will be making Psilomethoxin OTC in a GMP formulation from yeast using gene editing. We have a university partner who will be conducting clinical trials on Psilomethoxin on the way towards an FDA indication.

The Church has sued Usona and others for defamation in Texas state court in Austin. The basis for our suit is that Usona is liable for their test of the anonymous unauthenticated sacrament due to the reckless disregard for the truth (actual malice) in the failure of their methodology to extract Psilomethoxin using methanol rather than water which Psilomethoxin is soluble in.

[-] jpritikin73@lemmy.today 2 points 6 months ago* (last edited 6 months ago)

Check out Santo Daime. When group behavior is the reference point, your conscious choice to harmonize with the group can help relieve varieties of self-centeredness including feeling entitled, lack of connection, and internal conflict. If your experience of psychedelics is only individual exploration then you have not had a chance to appreciate their full transformative potential.

jpritikin73

joined 6 months ago