First is clan Gangrel, they have finger claws and are unnaturally durable. Fiercely independent.
Second is clan Nosferatu, as sneaky as they are ugly. Great spies, and generally are monsters mostly on the outside.
Third is clan Tzimisce, who can craft the flesh of themselves and others. Their earned reputation for inhuman cruelty lends them the moniker "Fiends" in a world of bloodsucking monsters.
Fourth is clan Tremere, universally reviled blood mages. Wretches.