You could do an all female Ghostbusters, but the team should just happen to be all women and attention shouldn't be over drawn to that idea. They should have launched off of the 2009 video game franchise ad and just set this team in a different city. The 2016 movie was filled in Boston anyway. Have the OG team semi retired to reflect their real age. They want a cinematic universe out of the franchise? Just set different movies with different team in different cities. I would love a Kyoto, Paris, or New Orleans flavored Ghostbusters movies. Also, have the new New York team be based off the Extreme Ghostbusters cast. Don't necessarily imply that every story from the cartoon is canon, but it was a fun show that's being forgotten about.

edit: ohhhhhhhhhhh. Mexico City right around Day of the Dead. Make sure to have a Mexican anthropologist on the writing team though.