this post was submitted on 23 Jul 2024
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chapotraphouse

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Is there an over the counter anti-depression or anxiolitic med that you all use? (hexbear.net)
submitted 6 months ago by gueybana@hexbear.net to c/chapotraphouse@hexbear.net
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I hear ashwaganda actually helps? Anyone tried it?

Please do not recommend weed

And if you say alcohol you’re a very fine comedian

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[–] cosecantphi@hexbear.net 5 points 6 months ago* (last edited 6 months ago) (1 children)

Yeah it's hard to say how effective DXM is on its own, I'm not sure whether there's much research on it if any. But it's worth noting because it's definitely an SNRI. I know some people who don't tolerate Bupropion very well, in those cases it might be worth trying.

[–] rayne@hexbear.net 1 points 6 months ago* (last edited 6 months ago)

It's only an SNRI in its pro drug form, which is DXM. The reason it is prescribed with Wellbutrin is because it prevents your body from turning DXM into DXO, which is a powerful disassociative.

Additionally the half-life of DXM doesn't make it a very effective SNRI without changing the body's metabolism. The Wellbutrin is the component that changes metabolism.

I've done a lot of personal research with both DXM and it's active metabolite. And have some undergraduate education in pharmacology. I really don't recommend it.