I guess it depends what you value. I have a Framework 13, first generation. I run Linux on it and really enjoyed putting it together myself (I ordered the DIY option).

I absolutely love their ports. You swap in the ports you want. I normally run a USB C on either side (so I can charge from either side) plus a USB A on each side (the Framework 13 has two slots each side, I think the 16 might have 3 each side?). But I also have HDMI, Display Port, and micro SD in case I need them. I can hot swap them in.

Their guides are awesome. I broke a screen and was able to order another and replace it myself following their guide. When the time comes (probably in the next year or so) I'm planning on upgrading. A bit like a desktop, since it's been a few years it means replacing the motherboard (what they call the mainboard) and RAM since technology moves on. I"m pretty sure like all laptops the CPU is fixed to the mainboard, but you can upgrade RAM or storage without replacing the whole guts (assuming same slot type). In fact you can buy without some pieces and reuse stuff you have or buy from elsewhere to save some money.

When I eventually do it I'm planning on strapping the old mainboard to the back of my TV as a HTPC (replacing the old dying laptop currently there).

There are plenty of downsides. No touchscreen. I wish the screen was a little brighter, it's not bad but could be better (might be better with later models?). I replaced the hinges with their more resistant ones but the screen still moves if I carry it around with the screen open (not sure if it's still an issue on newer models).

I really value the idea of repairability and upgradeability. When I was younger you could swap a bigger harddrive or RAM into a laptop if you had a screwdriver (and sometimes even without), and repairing other parts was also possible. These days you're more likely to find the whole thing glued together. Framework lets you do your own repairs, and has guides to walk you through every step.

There are probably more downsides, but I do love it and would buy another in a heartbeat. But if there are special things you need then carefully check. For example last I checked they did not have a full size SD card reader module available (though of course you can use a regular external one if you really need to).