an inept hero who sets out to find the cure to a plague, but ends up fighting a larger evil. Yoshihiko is guided by a comedic Buddha, and accompanied by an incompetent wizard, a woman who wants to kill Yoshihiko because she thinks he killed her father, and a warrior who will kill Yoshihiko as soon as the warrior finishes telling Yoshihiko his stories.

That's a great setup. It's like a reverse 1001 Nights.