So many.

Hollow Knight, Celeste, Outer Wilds, Subnautica, Stardew Valley, Slay the Spire and Zachtronics games likely need no introduction. Then there's also...

Bug Fables. Incredibly satisfying Paper Mario-like which has thrived into its own thing.

Baba is You/Environmental Station Alpha, hempuli games. The former you've likely heard of, a logic Sokobon with truly mindbending puzzles deeper within (and a level editor!! god, I could gush about level editors for hours). ESA is an older hempuli metroidvania. If you're a fan of that genre, it's among the best.

Caves of Qud -- the best true roguelike IMO. It has so much flavor.

Slime Rancher [2], my beloved serotonin game.

Against the Storm, really well polished citybuilder that emphasizes the first few hours of citybuilding. It's a bit hard to explain here, but I'd suggest looking into it if you're a fan!

Symphony of War: The Nephilim Saga, my personal favorite tactical RPG.

I could go on but I gotta draw the line somewhere...