Probably not... There is a line I think.

For example, I had to install the my VPN app using a local .rpm package that I downloaded from their site. This works just fine, the only issue is that it will not update automatically, so any time there is an update, I have to uninstall the old version and install the new version.

However, that's extremely simple. Two commands and a reboot and voila.

I would say this is the order of preference with installing apps: flatpak > distrobox > layered package > local package.

I'm pretty sure you can get most stuff to work if you really want to. There's also a good amount of stuff online if you search for "silverblue" or "kinoite" rather than bazzite when you make your queries.