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How it works seems inconsistent. Sometimes it'll prevent negative effects, and others it won't.
For instance, I just got DM300. He used his exhaust. Before I took dmg from it, I used cleanse. Still was taking dmg despite this.
I've also had this happen when I'm on fire - doesn't cleanse it and I keep burning, even when it's maxed.
My best guess is that effects that cause damage are not debuffs. Weakened, blinded, rooted (or whatever it is called), charmed etc are debuffs. While poison and fire are DOT's.