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How it works seems inconsistent. Sometimes it'll prevent negative effects, and others it won't.
For instance, I just got DM300. He used his exhaust. Before I took dmg from it, I used cleanse. Still was taking dmg despite this.
I've also had this happen when I'm on fire - doesn't cleanse it and I keep burning, even when it's maxed.
If it gives you a box under your health bar, it's a status. If not, it's not a status. Weak, curse, blind and the like are gonna be status effects and can be removed. I believe that burn and bleed can also be removed. But it isn't a potion of purity. If you are standing in a fire, you will still burn, and you still take damage from normal sources like poison clouds.
That actually makes sense, and is a change from beta. Yet if you proc it before, you can walk through fire or poison
My best guess is that effects that cause damage are not debuffs. Weakened, blinded, rooted (or whatever it is called), charmed etc are debuffs. While poison and fire are DOT's.