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Alzheimer's Fully Reversed in Mice, Scientists Say (futurism.com)

submitted 1 day ago by artifex@piefed.social to c/science@lemmy.world

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In our latest attempts to make lab rats immortal, a new compound has been shown to reverse late stage Alzheimer's disease in lab mice. This is a rare case where the title isn't even clickbait.

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[–] piconaut@lemmy.ca 6 points 1 day ago (1 children)

Yeah, I didn't read the whole thing but apparently only in 5xFAD mice. I wish they would have also tried it in a Tau model like PS19.

[–] SaveTheTuaHawk@lemmy.ca 4 points 14 hours ago (1 children)

Both pointless. Mice do not get neuronal loss like human disease. These diseases have been stalled for 30 years on animal models generating "high impact" manuscripts that go nowhere.

Meanwhile, in human research, just taking vaccines can lower AD incidence by 30%. For real, proven. Not "soon", not "within 5 years" . That is far mor relevant than animal model studies.

[–] piconaut@lemmy.ca 1 points 4 hours ago

If you're talking about the infectious brain hypothesis, I agree. I'm submitting a manuscript on this topic right now. I wouldn't say that all mouse studies are pointless though. People just tend to design and/or interpret them poorly due to ignoring limitations. Mouse and human physiology are in fact more dissimilar than the majority of researchers seem to acknowledge.