I think stamina up to 2 wheels, or whatever seems like enough mobility for a small fight or exploring. 2 seems to be a sweet spot for me then hearts to not be too squishy.

Take advantage of the mechanic of not being one shotted, if you have full hearts and keep those 3 hearts full.

Now I think I have enough hearts, around 10, to go back to stamina and try for a third wheel. I need the extra wheel to run away from those gloom hands. Lol.