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GOOD games with female protagonists?
(beehaw.org)
From video gaming to card games and stuff in between, if it's gaming you can probably discuss it here!
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Extremely retro, but currently available on the Mac App Store: Mess O' Trouble. It was a WorldBuilder game--think Infocom, but with static pictures you could interact with. I believe your choice of Daredevil Dawn or Fearless Frank had some impact on the gameplay if you got far enough, but child me never did.
Does this game exist on other platforms?
Doubtful, though it might be possible to emulate System 6 or System 7 and get it running on Windows or Linux.