But cancers aren't generally random mutations; they're specific mutations to specific genes (oncogenes) that tend to be associated with cell replication and planned cell death.

So it actually does make sense that you can target cancer mutations, since you're looking at a fairly small set of mutations (about 300, I think.) In any case, the body destroying its own pre-cancerous cells is an important mechanism for day-to-day cancer prevention that's already working in people, so it makes sense to try to strengthen and broaden the response.

Not all cancer is the same on a cellular level

I’m certainly not one to dismiss scientific progress, but call me skeptical about the 1,000th cure/treatment/vaccine for “cancer” announcement this year.

One imagines there are many cure/treatment/vaccines because there are many different cancers