NAMBLA. Those chuckle fucks at the North American Man/Boy Love Association really made it difficult for us members of the North American Marlon Brando Look-Alikes.

CRISPR is neither a refrigerator compartment or a Nestle candy bar

IYKYK. Took me forever to memorize, I had to look it up every time I came across it and no way I'll ever say it aloud.

i18n I know it's not technically an acronym but what a fucking obscure way to write a word that's going to be constantly around non-english speakers. All the other ones in this family are also quite obnoxious but i18n is especially awful.

FFS. As in, for fucks sake, we all know it's FFS?!

Edit: sorry, drunk after work and reread the question. FFS is my fav.

WDYM...

I don't know why, it just looks unpleasant.

After 20 years in EMS, (see how it starts immediately - Emergency Medical Services), The whole bloody damned field is nothing but acronyms for as far as the eye can see.

From BPM - Beats per minute, to ABC - Airway, Breathing, circulation, (which today is more like ACB - Airway, Circulation, Breathing) to OPQRST - Onset, provoke/pallation, Quality, Region/Radiation, Severity, Time to A-Fib - Atrial Fibrillation to SOB - Shortness of Breath.

I hate them all........

YMMV. That one took me FOREVER to figure out.

ATM. Friends use it for 'at the moment', but all I see is ass-to-mouth.

It bothers me when OO doesnt stand for "object oriented"

iirc just because i dont know what it means

PICNIC. problem in chair, not in computer.