I have run Fedora for over a decade and switched to Bazzite a couple years ago for my desktop (Fedora still on my server).
In short, yes, but I wouldn't recommend it. You can learn what you need to directly on Bazzite. If you're looking for help, Bazzite is most similar to Fedora Silverblue (not regular Fedora) under the covers. The differences between regular Fedora and Bazzite are substantial enough that you'll run into some things you'd need to research twice, once for Fedora then again for Bazzite. Keep it simple and just use Bazzite.
If you want or need a distribution with a different focus, you should look at the other Universal Blue (ublue) options. Bazzite is built on ublue for gamers, but uBlue also builds for other use cases. Aurora for general desktop, Bluefin for workstation, and uCore for servers.