@LSD NeuralDSP, Fabfilter, Pigments, Kontakt, Blyss and others from Kush, Kclip, sometimes Waves 14 stuff, and Valhalla. If Wine makes it work, it should all be fine.
The only sad thing would be that all the old projects are based on Ableton, but well, that's survivable :)
@sbeak ext4 unless you have a concrete use case for btrfs, like snapshots on a backup drive etc... just my two cents