shreddy_scientist

joined 3 years ago
 

Stark racial and ethnic disparities in Alzheimer's disease (AD) and related dementias (ADRD) have been documented, largely attributable to the impact of social and structural drivers of health. The structural drivers of health include the institutions, practices, cultural norms, and policies that dictate the inequitable distribution of the social determinants of health (SDoH), defined as the conditions where people live, work, play, and age, and consist of various forms of systemic oppression including structural racism. The overlapping effects of race and place on health have been studied extensively, with an increased focus on the operationalization and measurement of “place-effects” on health through neighborhood characteristics and the built environment. Previous studies have demonstrated associations of place-based SDoH with cardiometabolic health and cognition. However, research studying the relationship of place-based SDoH with ADRD-associated neuroimaging and plasma biomarkers is still limited.

Biomarkers serve as proxies for underlying pathological changes and can play a crucial role in the detection of etiology underlying cognitive decline and ADRD. More specifically, neuroimaging biomarkers of brain structure and function, assessed using magnetic resonance imaging (MRI), are helpful in the early detection of disease processes and prognosis for progression. Additionally, numerous blood-based biomarkers have recently emerged as candidates for improved diagnosis and management of ADRD, along with a demonstrated need to examine varying SDoH profiles in correlation with these biomarkers due to observed differences in biomarker levels by medical comorbidities. Plasma biomarkers have been associated with brain health differences assessed with neuroimaging, most notably with lower total gray matter brain volume and higher amyloid deposition. Importantly, abnormal plasma amyloid β 42/40 ratio helps in identifying those with higher dementia risk, while phosphorylated-Tau 181 has been shown to increase with clinical severity of AD.

 

The Earth's magnetosphere acts as a protective shield against the solar wind—a stream of charged particles from the Sun. This interaction results in a large-scale electric field in the magnetosphere, known as a dawn-dusk convection electric field, playing a crucial role in disturbances such as the storm-time ring current and substorms. We explored the quasi-steady large-scale electric fields and the role of space charge in the magnetosphere by using global magnetohydrodynamics (MHD) simulations. When the interplanetary magnetic field is southward, a substorm growth phase begins. The large-scale electric field is in a relatively stable condition, in particular, on the dayside. In the MHD simulation, the positive space charge dominates the duskside magnetosphere, while the negative space charge dominates the dawnside. If the electric field is purely caused by the space charge deposited in the magnetosphere, the direction of the electric field will be in the dusk-dawn direction. However, the dawn-dusk electric field is established in the magnetosphere due to continued plasma motion interacting with the magnetic field. It is suggested that the magnetosphere maintains dynamic equilibrium through a balance of energy flow from the solar wind to the ionosphere. These insights improve our understanding of magnetospheric convection and the magnetospheric system.

[–] shreddy_scientist@lemmy.ml 6 points 1 month ago* (last edited 1 month ago) (3 children)

Not sure what's up with Nature's website on your end, but here's the link that's working for me to access the paper, which was published today (10-3-25): https://dx.doi.org/10.1038/s43018-025-01054-6

Nonetheless, a paper from 6 years ago studying a receptor found on almost half of immune cells should have more current information available by now, if not already. In science, we build on the shoulders of giants and try to expand on the knowledge they helped us understand. Additionally, the older study examines SLAMF6's function across health and disease, so it's much more generalized. The new study aims to provide additional context for the earlier findings and focuses on acute myeloid leukemia in particular. I have a PhD in immunology, and it's astonishing how little we actually understand about the subject. All in all, we understand the ocean better than the immune system, even though there's more we don't know about the ocean than we do. Even crazier is that most of our current understanding in immunology is actually for a rat's immune system and not humans! But you're not wrong to be cautious, all research papers should be read with a healthy amount of scrutiny. A wise man told me in undergrad that half of what we'd cover in the course would be incorrect, we just don't know which half.

[–] shreddy_scientist@lemmy.ml 5 points 1 month ago

I had no idea what the heck a water curtain test was and just I looked into it. Engineers use this test to verify that the structure’s drainage, wind‑load, and splash‑resistance systems work correctly. At the same time it creates a striking visual display of a rainbow‑like mist, which also highlights the bridge for the public and media.

[–] shreddy_scientist@lemmy.ml 13 points 1 month ago (4 children)

1/4 of all mammals are bats 🤯

 

In 2005, Cassini found the first evidence that Enceladus has a hidden ocean beneath its icy surface. Jets of water burst from cracks close to the moon’s south pole, shooting ice grains into space. Smaller than grains of sand, some of the tiny pieces of ice fall back onto the moon’s surface, whilst others escape and form a ring around Saturn that traces Enceladus’s orbit.

[–] shreddy_scientist@lemmy.ml 5 points 1 month ago (5 children)

As long as the revolt leads to a revolution, which seems to be the natural order of things, any human even vaguely similar to him would never hold that seat again. Igniting the fire which leads to his own removal from office doesn't seem like a power move. Unless he's playing 4D chess I can't comprehend, he's simply acting as a dictator before that's official. This should unquestionably result in his removal from office, unless the majority of citizens are brainwashed...which I haven't seen up to this point.

[–] shreddy_scientist@lemmy.ml 28 points 1 month ago* (last edited 1 month ago) (19 children)

There's ~35,000 US troops actively deployed on US soil because of this narcissist. At what point do the people collectively revolt? I live in a relatively large city in the western US, and regularly disheartened by the small turnouts to protest these blatant violations of our rights...

[–] shreddy_scientist@lemmy.ml 8 points 1 month ago (1 children)

kDrive and Proton Drive both fit the bill here, plus either option would drastically increase the privacy of your data compared to OneDrive.

[–] shreddy_scientist@lemmy.ml 4 points 1 month ago

Well said! It's soo blatant that in most cases I'd assume they were aiming to hide it in plane sight...but this team isn't smart enough to try and have that be their game plan.

[–] shreddy_scientist@lemmy.ml 16 points 2 months ago (2 children)

SoundCloud is pretty cool, especially when compared to Spotify. I've been really liking the https://sc.maid.zone/ SoundCloud frontend recently, makes it more private and you can download the songs on the same page you can listen to them. But all in all, it really just comes down to your opinion regarding if you should talk positively about it.

[–] shreddy_scientist@lemmy.ml 8 points 2 months ago

Yep, cellulose is a beta pleated sheet, unlike carbs/sugars, which are alpha helices. We're always ready to breakdown the alpha helices form of sugar, but due to the molecular structure of cellulose, we need help. This is were these enzymes come in from our microbiome. All this also ties into how in Western countries, most folks tend to be unable to breakdown cellulose due to the lack of the specific bacteria in our biome capable of producing this enzyme. However, in African and Asian countries, these bacteria are common place, so these cultures have been able to digest cellulose for ages!

[–] shreddy_scientist@lemmy.ml 94 points 2 months ago (1 children)

While Nebula is a creator‑owned ad‑free video service, it's truly just a conventional centrally‑hosted platform collecting user data like most sites. So while ad‑free, it has no focus on privacy as its privacy policy shows standard analytics and tracking typical of most subscription services. This being the case, it's not a privacy respecting alternative to YouTube like Peer Tube much at all unfortunately.

[–] shreddy_scientist@lemmy.ml 8 points 2 months ago

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