Need to make sure you hoard those hundreds of potions and wheels of cheese "just in case" 🧀🧀🧀

RDR2 has one of, if not my favorite, inventory systems. Your own 'backpack' that had a weight limit and could only carry smaller things. Big things you'd have to lug onto the back of your horse or find a cart. All of your equipped weapons are displayed on your person. If you want to swap weapons you have to run back to your horse and exchange weapons at your saddle bags

This is my line in the sand too. I couldn’t play Witcher 3 more than the first hours because of the inventory management.

I often find mechanics that only exist to waste time incredibly annoying. In the case of loot, a limited inventory is kind of that. You could absolutely just portal/teleport to town, sell your stuff, and then get back to playing. There's no challenge involved, EXCEPT that it wastes your real-world time.

I liked the pets in Torchlight for this reason. You could send them off to sell loot, while you kept playing the part of the game that's actually fun.

One exception is something like Resident Evil, where the choice is relevant to the gameplay directly. But even then, I would've preferred limits on individual elements (Only X weapons, only X healing items, etc.) and having extras automatically stored.