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this post was submitted on 13 Dec 2024
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Not to nit but we absolutely do not know the root cause of Alzheimer’s disease. Not that prions are good or anything.
Yeah, sorry, didn’t mean to imply that’s all that is going on with Alzheimer’s, but I was under the impression that prion formation/presence in neurological tissue was extremely highly correlated with the condition, though the precise mechanism of their effects aren’t yet well understood. Then again, I haven’t seriously looked into that stuff since my grandfather passed from it a while ago.
Sorry about your grandfather. There's probably more than one mechanism for alzeimers (not an expert), but amaloyid plaque formation, which is definitely A way to develop alzheimer's, is indeed a prion like event. I'm not sure if "prion" has some hyper-precise definition but the ideas similar: you get one amalyoid protein that misfolds, and acts as a nucleation site misfolding and agglomerating others.