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Karmic Dice - yes or no?
(bg3.wiki)
Baldur’s Gate 3 is a story-rich, party-based RPG set in the universe of Dungeons & Dragons, where your choices shape a tale of fellowship and betrayal, survival and sacrifice, and the lure of absolute power. (Website)
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On if you have no clue what you're doing.
Off if you're good at making OP characters and familiar with 5e.
It always makes rolls favor the one rolling, with a bigger bonus the more they've failed. So if you have a low attack bonus and miss frequently you'll hit more often. But if you have a tank with 22 AC, they'll also get hit (and crit) far more often with it on.
I'm fairly familiar with 3.5 and pathfinder 1 rules but never played 5e, how would it translate in terms of character building?
Severely overqualified. 5e is much simpler than 3.5 and PF1. If you're familiar with those, you could probably even make fairly good builds in Kingmaker and Wrath of the Righteous (the PF1 video games) without any guides.