this post was submitted on 19 May 2026
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so some months ago (around february) doctor increased the dosage of spironolactone we take, 1x25 mg per day to 2x25 mg per day. at first there were no noticeable side effects, but as time went on we started feeling more stressed and depressed and on the verge of crying randomly. it continued to get worse to the point of frequently thinking about suicide very often (began about a month ago).

at some point we thought "this is not a usual amount of feeling trash, even with all that is going on in life". we decided that it might be one of our medications; we use estradiol patches and spironolactone. genetics make it so AFABs in our family often have such mental health issues, so we didn't deem it too out of the question that it was playing a factor, even if such side effects weren't common with the medication usually.

other side effects included sometimes having terrible muscle coordination, and frequently panicking in general. more recently, walking was sometimes a challenge. not exactly hard, but it would not be in a straight line at all hehe. crying of stress became a common occurrence too.

so anyways last friday we just decided to stop taking spiro, and the depression just like went away. we made some yummy food and actually started getting some stuff done we really needed to! it was shocking how quick we felt better.

as for antiandrogens, monotherapy with patches seems a little tricky, although perhaps that may have changed now. our current plan is just to continue without spiro and get orchiectomy if possible.

there isnt really a specific reason we are posting, we just thought it would be an interesting experience to catalog for the internet and the world as a whole. yay science!!

we will be showing our plushies extra appreciation tonight for sticking around and keeping us sane x3 please do so for yours too they deserve it

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[โ€“] hildegarde@lemmy.blahaj.zone 4 points 2 days ago (1 children)

Cypro is not approved for use in the US which is the main reason they give us spiro.