this post was submitted on 28 May 2026
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A hormone-free pill, called YCT-529, that temporarily stops sperm production by blocking a vitamin A metabolite has just concluded its first safety trial in humans, getting a step closer to increasing male contraceptive options

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[–] ryannathans@aussie.zone 21 points 4 days ago (1 children)

Still impacted by the major limitation that sperm are matured for three months, so it only becomes effective after three months of consistent use

[–] Solumbran@lemmy.world 10 points 4 days ago (1 children)

Doesn't seem that big of a deal, all things considered.

[–] ryannathans@aussie.zone 24 points 4 days ago (2 children)

Medication non-adherence is a pretty big deal when it comes to contraception. This isn't some chronic disease where a drop in efficacy can be tolerated or not noticed. Contraceptives need to have high efficacies, to the point where it is all but guaranteed to work. Not seeing results for months affects medication adherence

[–] HyperCube@fedia.io 19 points 4 days ago

House Season 4 Episode 5:

(House to Cuddy) And I know when my Vicodin isn't Vicodin. Do you know when your birth control pills aren't birth control pills?

[–] Solumbran@lemmy.world 6 points 4 days ago (2 children)

Horrible side effects are also a big issue and people don't give much of a shit about that when it comes to female contraceptives.

[–] ParlimentOfDoom@piefed.zip 5 points 4 days ago (1 children)

They do. However, those side effects are being compared to the alternative - pregnancy can be a major health risk for a woman.

Men don't have that comparison to justify the side effects against.

[–] Solumbran@lemmy.world 0 points 4 days ago (1 children)

It takes two to make a baby.

Putting the whole burden on the ones with ovaries (that are already a big fucking burden on their own) is absurd.

[–] ParlimentOfDoom@piefed.zip 4 points 4 days ago (1 children)

I'm aware. I'm saying from the standpoint of medical science, that's the benchmark being used.

Organism 1 taking Med A causes health issues. Not taking Med A suffers no ill effects.

Organism 2 taking Med B causes health issues. Not taking Med B could suffer worse I'll effects.

Approving Med A to be taken by Organism 1 in order to prevent Organism 2 from suffering ill effects...is not how medication testing is done.

[–] Solumbran@lemmy.world -2 points 3 days ago

Yes, but if at some point the benchmark being used is obviously, undoubtedly flawed on a matter that can be solved, then it's time to ignore the benchmark.

The medical sector is always loooving to make exceptions and ignore rules, but when it comes to women's health suddenly the protocol is set in stone, that seems pretty convenient for a sector that is pretty well known to be extremely set in their sexist ways.

[–] coronach 2 points 4 days ago

I know someone that eventually went with an IUD because the various pills she tried made her feel extremely emotionally unstable. Really shitty situation.