ryannathans

5 million people in a country the size of China, Russia or the US would have drastically different outcomes to 5 million people in a country like New Zealand

Anthropic was started from all the safety engineers that left OpenAI over safety concerns

Lol?

IBM 1979 training manual

Anthropic's opus 4.8 is well beyond a junior dev. Most of the time it outperforms senior devs. Then there's mythos we don't have access to yet. We're fucked. Even if human R&D stops now

What is the picture on the right from?

I linked that paper because it was about the mechanism, but there's definitely papers going around where study participants ate the same excessive diet (and carbs) where the intervention group ate whey protein too or something to that effect and lost visceral fat

I wouldn't be surprised if improving protein intake or resolving some specific amino acid imbalance (relative to each other or carb intake, given some amino acids can be created from carbs) or deficiency improves insulin sensitivity and glycemic control

As far as a mechanism goes, my understanding is that high quality complete protein stimulates metabolic changes in gut microbiota. Not changes in species so much or diversity, but activating amino acid regulated pathways and metabolism. Diet quality is typically poor in those with high visceral fat, even if from a very high level perspective macro nutrient targets are hit.

This is quite interesting because as far as I understand, increasing protein intake increases insulin release.

This paper from nature is interesting and one of the few that go into looking at potential mechanisms: https://www.nature.com/articles/s41598-021-94916-9

Shareholders don't pay out of pocket for losses

No....

There's numerous studies if you bothered to search. These off the top of the first search engine I try:

Huang G, Pencina K, Li Z, Apovian CM, Travison TG, Storer TW, Gagliano-Jucá T, Basaria S, Bhasin S. Effect of Protein Intake on Visceral Abdominal Fat and Metabolic Biomarkers in Older Men With Functional Limitations: Results From a Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2021 Jan 8;76(6):1084–1089. doi: 10.1093/gerona/glab007. PMID: 33417663; PMCID: PMC8140050.

Merchant AT, Anand SS, Vuksan V, Jacobs R, Davis B, Teo K, Yusuf S; SHARE and SHARE-AP Investigators. Protein Intake Is Inversely Associated with Abdominal Obesity in a Multi-Ethnic Population. J Nutr. 2005 May;135(5):1196-1201. doi: 10.1093/jn/135.5.1196. PMID: 15867303.

CK, Cooper BC, Toth MJ, Gastaldelli A, Arabshahi A, Barnes S. Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal women. Fertility and Sterility. 2007 Dec;88(6):1609–1617. doi: 10.1016/j.fertnstert.2007.01.061. PMID: 17412329.

Christie DR, Grant J, Darnell BE, Chapman VR, Gastaldelli A, Sites CK. Metabolic effects of soy supplementation in postmenopausal white and African American women: a randomized, placebo-controlled trial. American Journal of Obstetrics and Gynecology. 2010 May 1;203(2):153.e1–153.e9. doi: 10.1016/j.ajog.2010.02.058. PMID: 20435291.

It's very well established that increased protein intake reduces abdominal fat in pretty much every population

Should and needs to be are different things

There is generally no such consent required in public in most countries