this post was submitted on 13 Jun 2026
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Stanford scientists regrow lost cartilage and reverse arthritis in major breakthrough (www.sciencedaily.com)
submitted 20 hours ago by sanitation@lemmy.today to c/technology@lemmy.world
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[–] pageflight@piefed.social 17 points 15 hours ago (2 children)

When they compared cartilage from young and old mice, they found that levels of 15-PGDH approximately doubled with age. To test the idea, researchers treated older mice with a small molecule drug that blocks 15-PGDH activity. [And cartilage regrew.]

Sounds very promising! I couldn't figure out the peer-reviewed-ness status.

[–] masterclass@lemmy.world 4 points 7 hours ago (1 children)

Yeah but while PGE2 promotes cartilage repair, it also plays roles in inflammation, fever, and gastrointestinal issues. If PGE2 levels rise too high or in the wrong context, it could cause unwanted inflammation or side effects similar to NSAIDs (e.g. stomach irritation).

[–] NocturnalMorning@lemmy.world 1 points 3 hours ago

I think I'd be okay with some stomach irritation to regain use of my knees in my old age.

[–] Tollana1234567@lemmy.today 2 points 11 hours ago

in mice though, since none of these recent one works in humans yet.