This is a most excellent place for technology news and articles.
This would be amazing for my wife. I mean I guess it would have been amazing if she still had her original knee. Maybe it'll be amazing for the other knee one day.
Probably worth adding "in mice" to the title
Good. Biological aging is nothing more than a series of processes, not an inherent property of atoms, and it's time we start getting serious about anti-aging and life extension.
But probably not, seeing what the world is like.
Its mostly billionaires who will be able to benefit from life extension... do you really want a world where trump, musk, and all their silicon valley friends rule the world until they turn 300 years old?
Billionaires, and everybody living outside the US
So essentially Altered Carbon?
Why do you think that? We already benefit from life extension. And why only 300?
If you're that worried, start working towards killing them. Seems like it's going to be necessary step either way to correct many problems in the world. What's one more reason for the pyre?
How about not life extension but quality of life extension instead (e.g. this post)
I didn't realize people weren't being serious about it this whole time. The tens of millions of dollars of research grants seemed pretty serious.
LOL that pays for a focus group for branding. You can't be serious.
I remember when I was a senior in high school back in the late 90s, my biology teacher mused one day that ours might be the first generation to not die of old age. I don't know if I'm anywhere near as optimistic now as he was then, but it is incredibly exciting to think about. There have been a slew of discoveries over the past 20 years that have been building towards this, and it's all been very fascinating. No idea if this is the grail or not, but it certainly seems like an important piece of the puzzle.
my biology teacher mused one day that ours might be the first generation to not die of old age.
Good for you that it was not the history teacher.
not dying of old age is a stretch. probably not dying young of certain diseases has improved.
Americans, we get it, you have no healthcare system worth the name. Stop assuming nobody else worldwide can get the meds either.
Or maybe you could show a little sympathy once in a while
You try running into comments thinking they're the only nation on earth in every health article and see how long you stay sympathetic.
Exactly. Functional public health systems will assess patient outcomes and the expenditure in money and resources to determine what treatments get approved.
The odds are pretty good that - if this works out - this will be on the list of approved treatments straight away. Surgery is an expensive and high-load pathway for public health systems. A non-surgical treatment that gives good outcomes is such a win-win for both patients and public health systems that it almost doesn't matter how much it costs.
When they compared cartilage from young and old mice, they found that levels of 15-PGDH approximately doubled with age. To test the idea, researchers treated older mice with a small molecule drug that blocks 15-PGDH activity. [And cartilage regrew.]
Sounds very promising! I couldn't figure out the peer-reviewed-ness status.
in mice though, since none of these recent one works in humans yet.
This and then the new about regrowing teeth. Its a very exciting time in medicine.
Ready for someone to tell me why this unfortunately won't work / become mainstream
Well, this same drug (working name MF-300) is a PDGH-15 inhibitor and has already been through phase 1 human trials for a separate condition.
Because PDGH-15 also causes age related muscle weakness.
Now, PDGH-15 also plays a role in cancer prevention, and there may be a few other less obvious functions.
I don't know if the results of the phase 1 trials have been published yet, but it's been a while since I checked.
I've been hearing about MF-300 for a little under a year, and with these same claims about restoring cartilage.
Money, usually. Or cancer. God i sound depressing 😄
Money cancer.
Ah, the billionaires again.
Finally some good fucking news.
I’m in this thumbnail and I want that right now.
Just in time for me to get old!
Wrong end of the stick, as usual
Amazing!
