this post was submitted on 31 Jul 2026
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I shattered my humerus (upper arm bone) badly, and needed major surgery, so I was in bad pain for a while, exacerbated by the fact that I'm a big whiney baby.
I absolutely refused any opiates for pain, knowing I'd get hooked, so I stuck with massive does of Advil, which worked okay. When I was near the end, almost out of it, I discovered that doctors were often recommending a combo of 1 Tylenol and 2 Advil for pain, claiming that the pain-killing power approached the level of an opiate, without any chance of addiction. I tried it, and the result was AMAZING! It really worked well. I wish I'd known about it when I first came out of surgery, instead of weeks later, when the pain had subsided for the most part.
Also, the Advil is processed by the kidneys, and the Tylenol is processed by the liver, so none of your organs are overtaxed. It's still not a good idea for those who are taking blood thinners.
I've also noticed that Advil now sells their own combo with acetaminophen.
how did you get hurt so badly?
Can confirm. Every time I go in to get my INR checked, I am always asked if I have taken any tylenol products. I don't fully remember why it's not a good idea, but I wanna say it might increase blood thickness, which increases potential for a blood clot. And I don't need to explain why that is a bad thing.
Edit:
I am wrong. Another person corrected and it's NSAIDS like ibuprofen and aspirin that can cause issues. Specifically raising the risk of bleeding. I thank them for the correction so I don't just spread misinformation.
You'd think I remember this considering I have been on blood thinners for over a decade, but my memory has never been the greatest for over a decade.
I think you’re mistaken: it’s not Tylenol but rather NSAIDs, like Advil, Aleve, and aspirin.
Harvard Health Publishing: Bad mix: Blood thinners and NSAIDs
Maybe I am mistaken. It's one of those things I have heard enough that I don't think about it and it becomes background that my brain kinda tunes out of my thoughts.
If you take blood thinners, you absolutely should think about it, otherwise you may be taking exactly the painkillers they’ve been telling you not to take.
I really should think about it more. You are absolutely right. My problem is I almost never need painkillers, so I almost never need to worry. Not a good excuse in the slightest, though.
Good one. We also use NSAIDs (doesn’t have to be Advil/ibuprofen specifically) & Tylenol (AKA acetaminophen/paracetamol) in combination when needed.
It’s worth noting that Excedrin is a combination of aspirin (an NSAID), acetaminophen, and caffeine. https://en.wikipedia.org/wiki/Aspirin/paracetamol/caffeine