Manga

Maybe Yotsuba&!

But the one you should really read: "Interviews with monster girls"

It's about demihumans integrating into human society (think vampires and other mythical creatures). Except in the story, they're more like mutations that can occur, like an unusual eye color. Except of course the changes are much more severe.

The narrative uses this as a stand-in to make commentary on how we should treat people who are "different", as long as they don't do harm. With acceptance and understanding.

The main charachter is a teacher in a school with some of these demihumans (both students and faculty), and he goes out of his way to try to understand them. It is a series about accommodating the needs of others, especially when they are different in ways that you might have to have a long conversation about what it is like to be them, to really achieve that.