this post was submitted on 17 Feb 2026
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It’s bonded to an amino acid, lysine.
The lysine is cleaved from the prodrug in the bloodstream to release d-amph, not in the stomach. While I haven’t tried it (and wouldn’t recommend it), you should be able to get high from insufflation just fine, but the release curve will be much slower than if you were railing pure speed.
Your friends weren’t talking out of their asses completely. Your psychiatrist isn’t talking out of their ass either, but they’re conflating the mechanism of action that Vyvanse uses with a mechanism used by many other prodrugs, which is first-pass metabolism.
It has been nearly 20 years since I had the convo with my doc, so I definitely could be misremembering parts of it.