I've been into Anime since the 90s, always had friends and wasn't ostracized for it. Some people asked questions about tentacle hentai and Akira, but since was I never found any intereet in either all I could talk about was stuff I'd seen and I'd just tell em that.

I guess the closest thing to a real negative reaction was my mom walking in on the opening scene of Ranma 1/2 Movie 2, where Ranma, having been at the beach as a guy, was now running around topless as a woman. She didn't accept "that's really a guy who just got splashed with water."