C4d

I found Bean to be the best client - but it’s gone. What’s everyone using instead?

Predictably, it’s the 15-minute-city conspiracy crap.

The mayor of London, Sadiq Khan, said the strikes would have cost the hospitality industry £50m alone, and the suspension “shows what can be achieved by engaging and working with trade unions and transport staff, rather than working against them”.

“The result of a three-year inquiry by a group of the nation’s top academics, businesspeople and policymakers, the study warned that a generation of younger adults was being failed in particular – with 9 million having never worked in an economy with sustained average wage rises.”

So it’s not purely anecdotal then… link to the original paper is here.

“TEES VALLEY regional mayor Lord (Ben) Houchen's South Tees Development Corporation (STDC), responsible for Europe's largest brownfield regeneration project, is using Enron-style accounting to mask the remarkable deals it has struck with local businessmen and their effects on the body's finances, an examination of its latest accounts shows.

Epitomising the smoke-and-mirrors is the single most expensive project at the heart of Rishi Sunak's flagship freeport: the construction of a £113m quay on the south bank of the Tees, planned to serve green industrial companies such as the Korean wind turbine monopile manufacturer SeAH, which is building a plant next to it.”

Brexit. Benefits.

“Poll after poll has shown that the biggest reason for people not wanting to cycle is perceived danger. And anyone who has dared to ride a bike on unprotected roads will soon discover that a large part of this danger comes from pure illegality, not least the vast proportion of drivers who speed, especially on residential roads.

This neatly leads us to the other factor highlighted by the report, and its reaction to it: the howls of outrage if people politely suggest that people could perhaps be less of a danger to others when they drive.

Before the report’s launch, the only one of 10 recommendations highlighted in the media was the idea of removing the so-called tolerances in speeding offences, whereby you can currently go about 10% plus 2mph above a limit and not be penalised.”

The link to the parliamentary group report (.pdf file) is here.

“The ultimate problem is perhaps the lack of seriousness with which local authorities are regarded and the lack of seriousness with which councils are run. More than in 1890, our political culture is dominated by Westminster and Whitehall. We are an over-centralised polity. We do not take local government seriously enough to give councils significant powers and adequate resources and tax-raising abilities. And we do not take local government seriously enough for the powers and resources and revenue-raising abilities that local authorities do have to be used well.

Few take any serious interest in local government matters. An account of the government of a large city other than London will rarely get 12 paragraphs in an earnest newspaper, let alone the 12 pages of a fashionable transatlantic journal. The sort of individuals who in 1890 would manage major acquisitions and improvement projects for provincial cities as part of their civic roles are not often the local councillors of 2023. And why should they be? Local authorities have limited independence, apart from in making mistakes.

Local elections are largely treated as national opinion polls. Councils are expected to do a great deal, but with fewer resources and almost no real autonomy. This is a problem wider than Birmingham, even if the city provides a good illustration of it.”

Some footnotes from the author are here.

Abstract

As our planet warms, a critical research question is when and where temperatures will exceed the limits of what the human body can tolerate. Past modeling efforts have investigated the 35°C wet-bulb threshold, proposed as a theoretical upper limit to survivability taking into account physiological and behavioral adaptation. Here, we conduct an extreme value theory analysis of weather station observations and climate model projections to investigate the emergence of an empirically supported heat compensability limit. We show that the hottest parts of the world already experience these heat extremes on a limited basis and that under moderate continued warming parts of every continent, except Antarctica, will see a rapid increase in their extent and frequency. To conclude, we discuss the consequences of the emergence of this noncompensable heat and the need for incorporating different critical thermal limits into heat adaptation planning.

Zhao J, Xu L, Sun J, et al Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019 BMJ Oncology 2023;2:e000049. doi: 10.1136/bmjonc-2023-000049

Abstract

Objective This study aimed to explore the global burden of early-onset cancer based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwid.

Methods and analysis Incidence, deaths, disability-adjusted life years (DALYs) and risk factors for 29 early-onset cancer groups were obtained from GBD.

Results Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% between 1990 and 2019. Early-onset breast, tracheal, bronchus and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019. Globally, the incidence rates of early-onset nasopharyngeal and prostate cancer showed the fastest increasing trend, whereas early-onset liver cancer showed the sharpest decrease. Early-onset colorectal cancers had high DALYs within the top five ranking for both men and women. High-middle and middle Sociodemographic Index (SDI) regions had the highest burden of early-onset cancer. The morbidity of early-onset cancer increased with the SDI, and the mortality rate decreased considerably when SDI increased from 0.7 to 1. The projections indicated that the global number of incidence and deaths of early-onset cancer would increase by 31% and 21% in 2030, respectively. Dietary risk factors (diet high in red meat, low in fruits, high in sodium and low in milk, etc), alcohol consumption and tobacco use are the main risk factors underlying early-onset cancers.

Conclusion Early-onset cancer morbidity continues to increase worldwide with notable variances in mortality and DALYs between areas, countries, sex and cancer types. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden.