The main advantage to me is that I can work with Invidious as a backend, and whatever I configure there will reflect in Clipious as a client. So as I subscribe to new channels in Invidious, add or update playlists, etc, Clipious will reflect these changes accordingly. Advantages of selfhosting Invidious that indirectly benefit Clipious are of course built-in adblocking by virtue of how Invidious works, SponsorBlock support, and the ability to cache static assets, such as video thumbnails for faster load times, using a reverse proxy (Nginx is what I use). There's a lot more we could dive into beyond this, such as no Google account requirement (for enhanced privacy).

One area where the SmartTubeNext and YouTube ReVanced combo has the advantage is the convenience of being able to cast from your handheld device to your TV. Clipious/Invidious has no casting ability. But I can totally live without that.