Yeah, the professor loses and regains the use of his legs on numerous occasions throughout the comics. It's pretty wild.

He originally becomes crippled after fighting his archenemy... Lucifer.

His body is later destroyed during the Claremont run, after it's transformed into a brood. His mind is recovered, however, and the Starjammers--with Dr. Moira Mactaggert's assistance--manage to clone him a new body. Though it takes him a while before he can use it due to psychological pain.